The Grim Adventures of Billy and Mandy - Season 6 - Eps 21: Spidermandy
When Billy finds his "son" Jeff the Spider lying in his bed with "Spider Pox", he goes to Mandy for help to get rid of the giant spider. While ignoring Billy, the next morning Mandy awakens afflicted by Spider Pox too, developing four additional arms and the ability to produce spider web. Mandy's condition progresses and she completely turns into a giant spider, who captures Billy's parents and Grim. Grim tells Billy that, to cure Mandy, he must use the venom of the spider that infected her. While Billy successfully gives Mandy Jeff's venom, he also carried the virus and infected the people of the city, who have all turned into spiders.
About The Grim Adventures of Billy and Mandy

Title: The Grim Adventures of Billy and Mandy
First Air Date: 2001-08-24
Last Air Date: 2007-11-09
Status: Ended
Rating: 8.045/10 (from 958 votes)
Language: EN
Seasons: 8
Total Episodes: 184
Network: Cartoon Network
Genres: Animation, Comedy, Kids
Production Companies: Cartoon Network Studios
Synopsis
The exploits of the Grim Reaper, who has been forced into being the best friend of two children. A spin-off of the show Grim & Evil.
Cast

Greg Eagles
Grim (voice)

Richard Steven Horvitz
Billy (voice)

Grey DeLisle
Mandy (voice)

Vanessa Marshall
Irwin (voice)