Samantha Who? - Season 2 - Eps 3: The Pill
Desperate to regain her memory, Sam opts to join a clinical trial and starts taking pills for her memory. Sam's memories start coming back, but she doesn't like what she learns about her former self. Elsewhere, someone confuses Dena and Andrea as being a gay couple, which frustrates Andrea and sends her on the hunt to find someone hotter than Dena.
About Samantha Who?

Title: Samantha Who?
First Air Date: 2007-10-15
Last Air Date: 2009-07-23
Status: Canceled
Rating: 6.6/10 (from 75 votes)
Language: EN
Seasons: 3
Total Episodes: 35
Network: ABC
Genres: Comedy
Production Companies: Brillstein Entertainment Partners, ABC Studios, Donald Todd Productions
Synopsis
Samantha Newly has been a bad, bad girl. But thanks to an 8-day coma, she can't remember a thing. Fortunately her best friend Andrea is by her side with a cocktail and the 4-1-1 on every dirty deed. But the more Sam pieces together her past, the less she likes her old self. Maybe this is a chance to start over and do it all again.
Cast

Christina Applegate
Samantha Newly

Jennifer Esposito
Andrea Belladonna

Kevin Dunn
Howard

Melissa McCarthy
Dena

Tim Russ
Frank

Barry Watson
Todd

Jean Smart
Regina Newly