Supernatural - Season 1 - Eps 13: Route 666
Dean is contacted by his first love Cassie, an African-America girl, who asks him to come to Mississippi to investigate a string of racially motivated murders. Each murder is linked to a mysterious truck that seems to have no driver and leave no tracks. Sam is stunned to see this new side of his brother as Dean struggles to come to grips with the residual feelings he has for Cassie.
About Supernatural

Title: Supernatural
First Air Date: 2005-09-13
Last Air Date: 2020-11-19
Status: Ended
Rating: 8.3/10 (from 7744 votes)
Language: EN
Seasons: 16
Total Episodes: 327
Network: The WB The CW
Genres: Drama, Mystery, Sci-Fi & Fantasy
Production Companies: Kripke Enterprises, Supernatural Pictures, Wonderland Sound and Vision, Warner Bros. Television
Synopsis
When they were boys, Sam and Dean Winchester lost their mother to a mysterious and demonic supernatural force. Subsequently, their father raised them to be soldiers. He taught them about the paranormal evil that lives in the dark corners and on the back roads of America ... and he taught them how to kill it. Now, the Winchester brothers crisscross the country in their '67 Chevy Impala, battling every kind of supernatural threat they encounter along the way.
Cast

Jared Padalecki
Sam Winchester

Jensen Ackles
Dean Winchester

Misha Collins
Castiel