Supernatural - Season 1 - Eps 1: Pilot
Two brothers, Sam and Dean Winchester, witness their mother's paranormal death as children and grow up trained to fight by a distraught father who wants nothing more then to hunt down the thing that killed his wife. Sam escapes to college to start a new, normal life, but gets pulled back in after Dean shows up on his doorstep to tell him their father is missing. Following clues from an eerie phone message from him, the boys travel to a small town and encounter a vengeful spirit called the "Woman in White" who then starts to haunt Sam.
About Supernatural

Title: Supernatural
First Air Date: 2005-09-13
Last Air Date: 2020-11-19
Status: Ended
Rating: 8.3/10 (from 7744 votes)
Language: EN
Seasons: 16
Total Episodes: 327
Network: The WB The CW
Genres: Drama, Mystery, Sci-Fi & Fantasy
Production Companies: Kripke Enterprises, Supernatural Pictures, Wonderland Sound and Vision, Warner Bros. Television
Synopsis
When they were boys, Sam and Dean Winchester lost their mother to a mysterious and demonic supernatural force. Subsequently, their father raised them to be soldiers. He taught them about the paranormal evil that lives in the dark corners and on the back roads of America ... and he taught them how to kill it. Now, the Winchester brothers crisscross the country in their '67 Chevy Impala, battling every kind of supernatural threat they encounter along the way.
Cast

Jared Padalecki
Sam Winchester

Jensen Ackles
Dean Winchester

Misha Collins
Castiel