Family Guy - Season 12 - Eps 6: Life of Brian
Stewie and Brian travel back in time to 17th-century Jamestown and make too many close calls with changing history. Stewie decides to destroy his time machine, but comes to regret it when Brian dies after being hit by a car. Devastated by his death, the Griffin family goes out and adopts another dog from the pet store, Vinnie, who is quickly accepted by all the members of the Griffin family, other than Stewie, who can't get over the loss of Brian.
About Family Guy

Title: Family Guy
First Air Date: 1999-01-31
Last Air Date: 2025-03-16
Status: Returning Series
Rating: 7.38/10 (from 4502 votes)
Language: EN
Seasons: 24
Total Episodes: 432
Network: FOX
Genres: Animation, Comedy
Production Companies: 20th Century Fox Television, Fuzzy Door Productions, 20th Television Animation, 20th Television
Synopsis
Sick, twisted, politically incorrect and Freakin' Sweet animated series featuring the adventures of the dysfunctional Griffin family. Bumbling Peter and long-suffering Lois have three kids. Stewie (a brilliant but sadistic baby bent on killing his mother and taking over the world), Meg (the oldest, and is the most unpopular girl in town) and Chris (the middle kid, he's not very bright but has a passion for movies). The final member of the family is Brian - a talking dog and much more than a pet, he keeps Stewie in check whilst sipping Martinis and sorting through his own life issues.
Cast

Seth MacFarlane
Peter Griffin / Brian Griffin / Stewie Griffin / Glenn Quagmire / Tom Tucker (voice)

Alex Borstein
Lois Griffin / Tricia Takanawa / Loretta Brown / Barbara Pewterschmidt (voice)

Mila Kunis
Meg Griffin (voice)

Seth Green
Chris Griffin (voice)

Patrick Warburton
Joe Swanson (voice)

Arif Zahir
Cleveland Brown (voice)